Middle East Respiratory Syndrome Coronavirus Disease in Children
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Auteurs : Ziad A. Memish [Arabie saoudite] ; Jaffar A. Al-Tawfiq [Arabie saoudite] ; Abdullah Assiri [Arabie saoudite] ; Fahad A. Alrabiah [Arabie saoudite] ; SAMI AL HAJJAR [Arabie saoudite] ; Ali Albarrak [Arabie saoudite] ; Hesham Flemban [Arabie saoudite] ; Rafat F. Alhakeem [Arabie saoudite] ; Hatem Q. Makhdoom [Arabie saoudite] ; Sarah Alsubaie [Arabie saoudite] ; Abdullah A. Al-Rabeeah [Arabie saoudite]Source :
- The Pediatric infectious disease journal [ 0891-3668 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
Abstract
Background: In the initial description of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, many affected patients were adults with underlying medical comorbidities. Data on the clinical presentation and outcome of pediatric cases are lacking. We report the clinical presentation and outcome of MERS-CoV infection in 11 pediatric patients. Methods: The clinical presentation, demographic and laboratory data of pediatric patients with MERS-CoV were analyzed. Results: A total of 11 pediatric cases that tested positive by screening and confirmatory polymerase chain reaction for MERS-CoV were reported from Saudi Arabia. Two patients were symptomatic and the other 9 cases were asymptomatic. The median age of patients was 13 (range 2-16) years. There were 8 females and 3 males (2.7:1 ratio). One symptomatic patient died and the other symptomatic patient recovered. The diagnosis of patients was based on positive nasopharyngeal swabs on 10 patients. Conclusions: MERS-CoV disease is not limited to adults. Most cases of childhood MERS-CoV infection were asymptomatic and tested positive during contact investigation of older patients. Severe disease can occur in children with underlying conditions.
Affiliations:
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Le document en format XML
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<series><title level="j" type="main">The Pediatric infectious disease journal</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Pédiatrie</term>
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<front><div type="abstract" xml:lang="en">Background: In the initial description of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, many affected patients were adults with underlying medical comorbidities. Data on the clinical presentation and outcome of pediatric cases are lacking. We report the clinical presentation and outcome of MERS-CoV infection in 11 pediatric patients. Methods: The clinical presentation, demographic and laboratory data of pediatric patients with MERS-CoV were analyzed. Results: A total of 11 pediatric cases that tested positive by screening and confirmatory polymerase chain reaction for MERS-CoV were reported from Saudi Arabia. Two patients were symptomatic and the other 9 cases were asymptomatic. The median age of patients was 13 (range 2-16) years. There were 8 females and 3 males (2.7:1 ratio). One symptomatic patient died and the other symptomatic patient recovered. The diagnosis of patients was based on positive nasopharyngeal swabs on 10 patients. Conclusions: MERS-CoV disease is not limited to adults. Most cases of childhood MERS-CoV infection were asymptomatic and tested positive during contact investigation of older patients. Severe disease can occur in children with underlying conditions.</div>
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